Gattuso on transfers There will be very few signings

first_imgAC Milan manager Gennaro Gattuso has warned their supporters that they will not be as active as last summer in the upcoming transfer windowUpon the completion of Li Yonghong’s takeover last year, the Chinese businessman funded a major spending spree for Milan in order for them to re-claim their spot among the elite clubs in Europe.The Serie A side promptly signed up the likes of Leonardo Bonucci, Hakan Calhanoglu and Andre Silva, for this season. But so far, they have struggled to produce the kind of performances that were expected of them with head coach Vincenzo Montella being fired in November due to a poor start in their campaign.Since Gattuso was promoted from the youth ranks, the Italian has successfully guided the club back into contention for a spot in next season’s Champions League places and was recently awarded a new three year contract.It was expected that Yonghong would have provided Gattuso with substantial backing for the summer transfer window in order to build a side capable of mounting a challenge for the Serie A title, but the former midfielder insists that further spending is not the answer at the club and that it is up to both himself and his fellow coaches to ensure progression.“There will be very few signings and I am happy with that because these players are some of the best in the world,” said Gattuso, according to the club’s Twitter.Cristiano Ronaldo, JuventusSerie A Betting: Match-day 3 Stuart Heath – September 14, 2019 Considering there is a number of perfect starts so early in the Serie A season, as well as a few surprisingly not-so perfect ones….“Some of them will improve.“We will dip into the transfer market to sign a few players to help this team, but don’t expect 20 or 30 new signings. It is my duty is to coach the team.”???Gattuso: “We will dip into the transfer market to sign a few players to help this team but don’t expect 20-30 new signings. But my duty is to coach the team / Non vi aspettate 20-30 nuovi acquisti. Prenderemo qualcuno, ma il mercato non lo faccio io. Io alleno questi ragazzi”— AC Milan (@acmilan) 17 April 2018last_img read more

Mark Hughes bemoans Southamptons finishing

first_imgMark Hughes is disappointed with Southampton’s effort in front of goal as he admits they have anxiety in the final third after they failed to score in five straight games.More worrying for Mark Hughes is that this the first time since 2001 that Southampton have failed to find the net in five straight Premier League matches.Despite being the better side, Southampton failed to score against an organized Newcastle United defense as both teams settled for a point in the goalless game.Hughes is now encouraging his players to have more freedom in the 18-yard, be creative and take some risks if necessary.Premier LeaguePremier League Betting: Match-day 5 Stuart Heath – September 14, 2019 Going into the Premier League’s match-day five with a gap already beginning to form at the top of the league. We will take a…“Clearly we’ve got a little bit of anxiety in our finishing. Sometimes, we snatch at things, sometimes we need cool heads, or need to take a shot instead of an extra pass, which is understandable given our recent results.” Hughes told Sky Sports.“With a little bit more luck, I think we would’ve deserved the win, but we take the positive of the clean sheet and move on.“We’ve got this bit of an anomaly of results at home that we need to get over, as then we can really build our season.”last_img read more

Mac Allister signs for Brighton and gets loaned right away

first_imgThe 20-year-old Argentinean midfielder was bought from Argentinos Juniors, where he spent over three years playing.Brighton and Hove Albion have completed the signing of Argentinean midfielder Alexis Mac Allister.The player joined the English Premier League team immediately, as they are looking to avoid the relegation zone.The Argentinean started his professional career with Argentinos Juniors in 2016, where he spent three years, scoring eight goals in 56 matches.He signed a four-and-a-half-year deal with Brighton but will be loaned to Argentinos Juniors for the rest of the season.“The main reason I signed was because they came to Argentina looking for me, and they seemed very convinced about me,” he told Brighton’s official website.“They made a big effort, told me about their project and their ideas to keep growing in this league, and I liked their ideas. I liked what they said.”Webster knows there’s a lot of competition before he debuts Manuel R. Medina – August 24, 2019 Brighton and Hove Albion defender, Adam Webster, hasn’t debuted in the English Premier League because he knows the competition is fierce.“We kept in contact with Paul [Winstanley] and I was eventually able to come and sign everything,” he added.“I watch a lot of football and for me, the English league is the best in the world. It is above all the other leagues.”“That’s the challenge for me, to be able to perform in that league and to bring my contribution to this team,” he commented.“I feel I am a player who really likes to get on the ball, that is my style.”“I am really pleased I can go back for six months and help Argentinos, and these six months will help me a lot,” he said about returning to Argentina.“I will keep progressing with my team and be calm in my head. I’ll be able to enjoy playing for the club which has given me everything.”last_img read more

Cirque du Soleil Volta is coming to the Del Mar Fairgrounds this

first_img Posted: March 31, 2019 March 31, 2019 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – Cirque du Soleil’s Volta is coming to the Del Mar Fairgrounds this summer.The show will feature elements of the BMX world along with their aerial acts.Company manager Yannick Spierkel joined Good Morning San Diego to discuss the show. KUSI Newsroom, Updated: 9:13 AMcenter_img KUSI Newsroom Cirque du Soleil Volta is coming to the Del Mar Fairgrounds this summer Categories: Entertainment, Good Morning San Diego, Local San Diego News FacebookTwitterlast_img read more

Annual 4th Of July Parade Will Close Spur Hwy

first_imgKenai Chamber of Commerce President Johna Beech says the parade lineup will be from 8-10 a.m., on Trading Bay Road with the parade itself starting at 11 a.m. Beech: “Be mindful that we will be closing down the Spur Hwy from 11-12:30pm for the Parade. KPD does a great job of  rerouting traffic, but if you are in a hurry that’s not the day to be in a hurry. I can’t believe we are almost here, but it looks like it’s going to be another great 4th of July.”  The midway festivities are from noon to 4 p.m., with various vendors, a beer garden sponsored by Kassiks Brewery, and a kids carnival. The route for the parade starts down Fidalgo Ave, left on Willow Street, right on the Kenai Spur Hwy, and then a right on Main Street Loop. Facebook0TwitterEmailPrintFriendly分享Kenai’s Fourth of July Parade will close the Kenai Spur Highway for close to two hours on Thursday as floats line up for the annual event.last_img read more

Acura NSX holds its own against NSX GT3 Evo race car but

first_img 2019 Nissan Maxima review: The ‘four-door sports car’ that isn’t More about 2017 Acura NSX Enlarge ImageThe road-legal NSX is also significantly less expensive than the race car. Acura A good bit of modern GT racing involves keeping the playing field as even as possible. Sometimes that means ditching driven wheels or making less power than a road car equivalent, and all those changes tend to actually make the race car less capable in certain ways than its street-legal sibling, even if it’s still faster around a track. That’s the case with the Acura NSX and the NSX GT3 Evo, as a new video points out.Acura on Wednesday put out a new video comparing the regular ol’ Acura NSX with its racing counterpart, the NSX GT3 Evo. Racing driver Trent Hindman compares the two vehicles in a few different ways, including acceleration, braking and general ease of use. The video ends with a head-to-head lap around the Mid-Ohio course. 0 Share your voice Review • 2017 Acura NSX: A potent and proper follow-up to the original Acura Car Culture Hybrids Performance Cars Coupes It shouldn’t surprise anyone that, in standalone acceleration tests, the road-legal NSX walks away from the race car. The street car has a 573-horsepower hybrid V6 powertrain and all-wheel drive, whereas regulations limit the NSX GT3 Evo to rear-wheel drive and ditch all the hybrid components. Even though it’s some 1,000 pounds lighter than the road car, the race car just can’t keep up — but it wasn’t designed for acceleration alone.Even though the two cars share about 80% of their components, everything coalesces on the race car in a completely different way. The NSX GT3’s ridiculous aerodynamics, which would be ripped off the car on a standard driveway or speed bump, produce about 500 percent more downforce than the road car. When everything comes together, the NSX GT3 Evo can lap Mid-Ohio about 9 seconds faster than the street-legal NSX. But then again, the cars are built for two very different purposes, so the results shouldn’t surprise anybody too much. 2019 Acura NSX in its tangy, new huecenter_img 2020 Toyota Supra review: A solid sports car that’s rife with controversy 2019 Acura NSX review: Hitting its stride Acura Tags 55 Photos Preview • 2017 Acura NSX: Hypercar technology at a supercar price More From Roadshow Post a commentlast_img read more

Latif Siddique quits election race

first_imgLatif Siddique. File photoTangail-4 independent candidate Abdul Latif Siddique on Sunday stepped aside from the election race protesting attacks on his election campaigns by his rivals, reports UNB.A former Awami League minister, Latif Siddique went to the Election Commission in the city and informed it about his decision.Earlier in the morning, he made an announcement in this regard at his residence in the capital, according to his family sources.Before leaving the EC office, he distributed the copies of his statement among journalists to inform them about his decision.In his statement, Latif Siddique said, “Protesting the attacks by rivals, and instigated by the supporters of the local Member of the Parliament and police, I have decided to quit the election race.”Latif Siddique was admitted to Tangail General Hospital after he fell sick on Wednesday while continuing fast unto death programme protesting an attack on his motorcade during electioneering.Demanding withdrawal of the officer-in-charge of Kalihati police station and immediate arrest of those attacked his motorcade, the expelled AL leader who is contesting the election as an independent candidate from Tangail-4 (Kalihati) constituency, had gone on hunger strike on 16 December and fell sick on 18 December.Latif Siddique came under attack allegedly by the supporters of a local union parishad chairman backed by an MP at Soratail in Kalihati upazila that left 20 people injured.last_img read more

221 killed in road accidents during Eid vacation

first_imgPresident of Jatree Odhikar Sangrakkhan Parishad (Passenger Rights Protection Council) GM Quamrul Islam speaks at a press conference at the Jatiya Press Club in Dhaka on Wednesday, 12 June, 2019. Photo: UNBAt least 221 people were killed, 652 injured and 375 others got crippled in 185 road accidents on the country’s roads and highways in 12 days between 30 May and 10 June during the recent Eid-ul-Fitr vacation, reports UNB.Besides, four people were killed in five accidents on river routes, while 22 others lost their lives on rail tracks across the country during the period.President of Jatree Odhikar Sangrakkhan Parishad (Passenger Rights Protection Council) GM Quamrul Islam revealed it at a press conference at the Jatiya Press Club in the city on Wednesday.Accident research and monitoring cell members of the organisation prepared the report compiling published reports of 18 national dailies, six regional dailies and 10 online news portals.The report also stated that Eid journeys were a little bit comfortable this year compared to the past years due to the government’s initiatives as well as rationing in leave arrangements for Eid journeys.The number of road accidents, causalities and damages has declined slightly compared to the past years, it said.President of Freedom Fighters’ Foundation Ismail Gazi Delwar, former General Secretary of the Jatiya Press Club Quamrul Islam, General Secretary of the organisation Shamsuddin Chowdhury, Organising Secretary Abdullah Al-Zubayer, Finance Secretary Sayamun and Nahar Zidani were, among others, present.last_img read more

Iran to lift uranium enrichment above level in 2015 deal

first_imgA handout picture provided by the Iranian presidency on 3 July 2019 shows president Hassan Rouhani chairing a cabinet meeting in the capital Tehran. Photo: AFPIran on Sunday will announce an increase in uranium enrichment to 5 per cent, a concentration above the limit set by its 2015 nuclear deal, an Iranian official told Reuters, in a move signalling a deepening challenge to escalating US sanctions pressure.The declaration comes at a time of sharply increased US-Iranian confrontation, a year after Washington quit the pact and reimposed sanctions that had been lifted under the accord in exchange for Tehran curbing its nuclear work.”The main announcement tomorrow will be the increase of the level of enrichment to 5 per cent percent from 3.67 per cent that we agreed under the deal,” the official said on Saturday on condition of anonymity.In a sign of heightening Western concern, French president Emmanuel Macron said he and Iran’s president Hassan Rouhani had agreed to seek conditions for a resumption of dialogue on the Iranian nuclear question by 15 July.Macron’s office added that he would keep on talking with Iranian authorities and other involved parties to “engage in a de-escalation of tensions related to Iranian nuclear issue.”The deal is aimed at extending the time Iran would need to produce a nuclear bomb, if it chose to, to a year from roughly 2-3 months. Iran says its nuclear programme is only for peaceful purposes, such as power generation, and not to make bombs.Under its deal with six world powers, Iran can enrich uranium to 3.67 per cent fissile material, well below the 20 per cent it was reaching before the deal and the roughly 90 per cent suitable for a nuclear weapon.Iran’s semi-official Fars news agency reported that senior nuclear negotiator Abbas Araqchi would announce more cuts in its commitments to the pact at a news conference at 10:30am (0600 GMT) in Tehran.Sunday’s planned announcement is a setback for Britain, France and Germany, co-signatories of the deal who have pressed for months to persuade Iran to remain committed to the accord.Iran has said that the Europeans have done “too little, too late” to salvage the pact by protecting Iran’s economic interests from US sanctions.”Economic War”Washington tightened those curbs from May, ordering all countries and companies to halt all imports of Iranian oil or be banished from the global financial system. It has also dispatched extra troops to the region to counter what it describes as Iranian threats.In reaction to the toughened US sanctions, Iran said in May that it would scale back its commitments to the deal after a 60-day deadline to European signatories of the pact to protect Iran’s economic interests from US sanctions.However, Iran’s Rouhani said last week that all the measures taken by Iran were “reversible” if other parties to the deal fulfilled their promises.Leaving room for diplomacy, Rouhani said in a telephone conversation with Macron: “Lifting all sanctions can be the beginning of a move between Iran and six major powers.””The US sanctions are a full-scale economic war against Iran that could create more crisis in the region and in the world,” he told Macron, according to state TV.Ali Akbar Velayati, a senior adviser to Supreme Leader Ayatollah Ali Khamenei, said Iranian officials were unanimous in raising the level of uranium enrichment beyond the 3.67 per cent set in accord, in remarks posted on Khamenei’s officials website.”For example, we need uranium enriched to 5 per cent for use in the Bushehr (power plant) and this is a completely peaceful purpose,” Velayati said, hinting that this might be the first step Iran might take in raising the enrichment level.Iran’s main demand – in talks with the European parties to the deal and as a precondition to any talks with the United States – is to be allowed to sell its oil at the levels before Washington pulled out of the deal and restored sanctions.Iranian crude exports were around 300,000 barrels per day or less in late June, industry sources said, a fraction of the more than 2.5 million bpd Iran shipped in April 2018, the month before Trump withdrew from the nuclear deal.last_img read more

TVs Next Commercial Break Might Be the Pause in Your Binge EXCLUSIVE

first_imgSome outlets are willing to bet they will. “As binge-viewing happens more and more, it’s natural they are going to want to pause,” says Jeremy Helfand, vice president and head of advertising platforms for Hulu, speaking of modern-day couch potatoes. Hulu intends to unveil what it calls “pause ads” in 2019. When a user chooses to stretch, or get a snack, he says, “it’s a natural break in the storytelling experience.”AT&T also has hopes to use the pause to lend new momentum to TV advertising. The company, which owns DirecTV and U-verse, expects to launch technology next year that puts a full-motion video on a screen when a user decides to take a respite. “We know you’re going to capture 100% viewability when they pause and unpause,” says Matt Van Houten, vice president of product at Xandr Media, AT&T’s advertising division. “There’s a lot of value in that experience.”Many consumers think they can escape the usual barrage of TV pitches with new streaming-video services that run only a few ads, and sometimes even none. That notion has been bolstered in recent months by efforts from companies like NBCUniversal, which has experimented with running fewer ads in primetime. But TV  watchers may have to recalibrate their view. Media companies don’t want to lose the billions of dollars advertisers pay them each year. And consumers would have to submit to much higher prices for access to their favorite shows if commercials didn’t play some part in the overall experience. Indeed, Hulu offers its service at a higher price if customers want to avoid commercials completely.At a September conference held for advertisers, AT&T executives made the case that even new forms of video entertainment – including streaming – require ad support. “If we are to continue this pace of developing content of this quality in these volumes, then we need advertising to pay for some of the content,”said Brian Lesser, chief executive of the company’s Xandr unit, while speaking to reporters at the event. “I don’t believe – nor does anybody on the team believe – that subscription video on demand services could possibly pay for all the content being developed” without relying on money from advertising. The plans for pauses suggest new power in the media industry could go to those outlets that can establish a more direct tie to viewers. A linear TV network, after all, can’t necessarily make a regular event out of someone choosing to run to the kitchen for a bowl of pretzels.Even some of those more traditional media bastions are experimenting with new TV technology as well. CBS has tested technology that lets advertisers add tailored messages to national commercials seen by viewers using certain connected TVs. A retailer with a sale at an outlet 30 miles away could add a note to someone who lives close by, and a restaurant might tout its delivery service in a particular city or town. The network also is testing a system that lets it “split” ad slots  — sending an ad for a lower-priced car to a household owned by a young couple, or an ad for high-end technology to a TV watched by high-income consumers.The media companies will have to do more than gamble on consumers’ receptivity to the concept of seeing an ad at stops of their own choosing. “Just because you can doesn’t mean you should,” cautions Tim Hanlon, CEO of Vertere Group, a media and advertising consultancy.  He sees a lot of sense in “pause ads” that play off the moment when they are watched or are tailored to particular consumer occasions, but “if it’s simply inserting, let’s say a reverse-mortgage ad with a direct-response phone number? I don’t know if that aids the consumer experience.”Indeed, streaming fans have already balked at seeing promos turn up between videos. Some Netflix aficionados earlier this year protested a test in which the streaming giant flashed promos for its various programs in the seconds between the end of one selection and the start of another. Could real pitches from outside advertisers be next? Netflix has never run traditional commercials on its services and its executives have said they do not want to start doing so.Media executives say they will step carefully. “You do not want to deliver a longform advertisement in this situation,” says Hulu’s Helfand. “I think you have seconds to deliver your message effectively.”  He says the company expects to have “more than half of advertising revenue come from non-disruptive experiences” over the next three years. TV viewers may dislike commercial breaks, but Madison Avenue soon hopes to get them to watch ads during a very different kind of interruption.Coca-Cola struck advertising gold in 1929 by introducing the slogan, “The Pause That Refreshes.” In 2019, there is new hope in a similar concept: a refreshing pause that carries a word from a sponsor. Consumers have more power these days to avoid ads that get in the way of the viewing of their favorite shows, but maybe  —  just maybe — they will show interest in commercials that come on screen during interludes of their own choosing from long streaming sessions or on-demand playback.Imagine an ad for soda or beer that comes on the screen just as you decide to stop the action during a run of an episode of “Black-ish”  on Hulu to go to the kitchen for a snack, or a pitch for toilet paper that begins to move in the moments before you choose to halt the video stream for a bathroom break. And yet, there’s no guarantee viewers will welcome “pause-vertising” any more than they do the current crop of 30-second pitches. Ever since the DVR made its way into living rooms last decade, Madison Avenue has worked furiously to find new ways to keep commercials from being skipped or ignored. As more TV viewers indulged in fast-forwarding past ad breaks, marketers tried to get them to slow down by tucking secret codes and special scenes into their spots. Now they must identify even more aggressive methods of getting audiences to pay attention to their pitches.“Pause ads” have surfaced in the past. When companies like TiVo and ReplayTV were introducing early versions of the DVR to the marketplace, Coca-Cola and Universal Pictures signed up to place banner on ads on ReplayTV screens whenever customers opted to pause the show they had recorded. Today’s technology lets marketers add more sound and motion the proceedings. AT&T’s Van Houten suggests viewers might even seen interactive pause ads that allow them to “telescope” to more information from the advertiser with the click of a remote.Viewers could balk at having ads thrust at them in this new milieu, but the AT&T executive suggests that next year’s “pause ads” could simply be the next iteration of the “flying toaster,” those low-res screen savers that popped up whenever a user of the Apple Macintosh let the machine sit too long. In time, he suggests, consumers might prefer the pause pitches to other forms of TV commercials.Making the connection clear for consumers that the ads help subsidize their viewing will be important says Hanlon, so many of the new commercials might have to make clear they help to bring programming to the screen.Are viewers ready for a pause in viewing that becomes a moment of selling? “In the end, consumers will vote with their feet,” says Brian Sheehan, a professor of advertising at Syracuse University’s SI Newhouse School of Public Communications. Or perhaps their remotes. And definitely their wallets.center_img Popular on Variety ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15last_img read more

Texas School Standards Age of the Universe Erased

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Heavyweight galaxies puzzle astronomers Explore further Originally in the Texas school standards was this phrase: “concept of an expanding universe that originated about 14 billion years ago.” However, board member Barbara Cargill thought this wasn’t good enough. It was too definite. The standards now read, “current theories of the evolution of the universe including estimates for the age of the universe.” You can bet that the age of the earth is not listed in the Texas curriculum as about 4.5 billion years old — in spite of the fact that most of the people my age and older have known (or rather, estimated) this for years.There certainly are many different theories about the formation of the universe. Whether it was a big bang or a big bounce are two of them. Cosmologists and astronomers wonder about the rate of expansion in the early universe, and they debate the effects of gravity (not to mention its nature) as well as consider questions about the composition of the universe and the kinds of particles that exist. However, despite the questions that do exist about the origination of the universe, there is very little debate about its age. Right now, the latest estimate is that the universe is 13.73 billion years old, plus or minus 120 million years. This information is the latest from results from the Wilkinson Microwave Anistropy Probe (WMAP). While the age of the universe is likely to be fine tuned in coming years, it is extremely likely that it will remain in the neighborhood of 14 billion years. And few scientists see the age of the earth being cast in doubt as well. But it appears that cosmology could now be thrown into the fray of science v. religion. Until now, matters of space have been very little addressed in terms of religion. After all, couldn’t God have created the universe well before putting humans on Earth? But it appears that by working from Earth outward, some are becoming concerned. If God created humans on Earth just a few millennia ago, then Earth can’t be 4.5 billion years old. And if Earth isn’t as old as all that, surely the universe isn’t, either. It’s an interesting train of logic. And one that could result in all we know about space science being brought under attack.© 2009 PhysOrg.com Texas school standards next attack: Removing references to the age of the universe. Image source: NASA Hubble Space Telescope. Citation: Texas School Standards: Age of the Universe Erased (2009, April 7) retrieved 18 August 2019 from https://phys.org/news/2009-04-texas-school-standards-age-universe.html (PhysOrg.com) — The fight over the new education and curriculum standards for the public schools in Texas has been long and publicized. Most of the publicity, though, focuses on the school board’s focus on “intelligent design” as it relates to the biological question of evolution. Because evolution has long been contested in public schools, it is no real surprise that this has gotten the most play from the media. But one thing that hasn’t been mentioned as much is the fact that the Texas school standards also remove mention of the age of the universe. Long-standing ideas of cosmology are being challenged as well.last_img read more

Researchers show how historical contingencies constrained evolution of a yeast regulatory network

first_img More information: Intersecting transcription networks constrain gene regulatory evolution, Nature (2015) DOI: 10.1038/nature14613AbstractEpistasis—the non-additive interactions between different genetic loci—constrains evolutionary pathways, blocking some and permitting others. For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the evolutionary pathways of a transcription network that controls the response to mating pheromone in yeast. A component of this network, the transcription regulator Ste, has evolved two different modes of binding to a set of its target genes. In one group of species, Ste binds to specific DNA binding sites, while in another lineage it occupies DNA indirectly, relying on a second transcription regulator to recognize DNA. We show, through the construction of various possible evolutionary intermediates, that evolution of the direct mode of DNA binding was not directly accessible to the ancestor. Instead, it was contingent on a lineage-specific change to an overlapping transcription network with a different function, the specification of cell type. These results show that analysing and predicting the evolution of cis-regulatory regions requires an understanding of their positions in overlapping networks, as this placement constrains the available evolutionary pathways. Sacharomyces cerevisiae cells in DIC microscopy. Credit: Wikipedia. © 2015 Phys.org Explore further Citation: Researchers show how historical contingencies constrained evolution of a yeast regulatory network (2015, July 9) retrieved 18 August 2019 from https://phys.org/news/2015-07-historical-contingencies-constrained-evolution-yeast.html A team of researchers with the University of California has found a way to show how historical contingencies constrained the evolution of a gene regulatory network. In their paper published in the journal Nature, the team describes how they conducted a genetic analysis of brewer’s yeast in a way that allowed them to gain a new perspective on the regulatory network that led to the current genome of the group of fungi. Aaron New and Ben Lehner of Universitat Pompeu Fabra in Spain, offer a News & Views piece on the work done by the team in the same journal issue.center_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Evolution of a natural gene network explored by Yale researchers Journal information: Nature In this research effort, the team looked at historical contingency—where a sequence of events led to a present state in a biological context. In ordinary life, historical contingencies occur all the time, looking over the life a person has lived, for example, would reveal many such instances, where decisions were made that led to a new state, and where another decision was eventually made based on what had occurred thus far, and on and on—mapping historical contingencies over time leads to what is known as a regulatory network—a depiction that illustrates the impact of all the contingencies that have occurred. In the biological sciences historical contingencies apply to evolutionary changes that occur over a certain period of time, and the regulatory network allows researchers to see which changes were contingent on which prior changes. Such work is challenging, which is why the researchers chose brewer’s yeast to study—not only does it have a reasonably simple genome, as New and Lehner, point out, but there are also genetic engineering tools that have been developed for its study that can be adapted for use across more than one species.Studying historical contingency in organisms works because of the way genetics works—as a trait evolves, the genome changes. Also, sometimes, changes that occur are lost due to changes in the environment, but the genome retains some of the DNA that came about due to the original change, and that too can be used in creating a regulatory network. In this new work, the researches reconstructed the evolutionary path of two mating types in brewer’s yeast, dubbed “a” and “α”—both cause genes to be switched on when exposed to pheromones. As part of their analysis they were able to show the evolutionary path that the types took as each was impacted by events, leading to contingencies and thus were able to construct a regularity network. They were also able to show, as New and Lehner, note that understanding the evolution of individual genes must involve the evolution of regulatory networks.last_img read more

WB education minister inaugurates MAKAUTs placement portal

first_imgKolkata: The Maulana Abul Kalam Azad University of Technology (MAKAUT) today launched a placement portal for graduates of the affiliated colleges under it to help the students get proper placement offers. The state university’s portal, which contains information about students of 196 affiliated colleges under the university – MAKAUT, was launched by West Bengal Education Minister Partha Chatterjee. “The portal will cater to procuring placement assistance to all the students of the MAKAUT-affiliated colleges in engineering, technology, pharmacy, management, architecture and various other professional courses,” Chatterjee said after launching the portal. Also Read – Heavy rain hits traffic, flights It is a pioneering step and the first such initiative by any institution in the country, he said. The minister said he wanted students to avail this opportunity and asked all the MAKAUT-affiliated colleges to make the best use of the portal. “The talented students will be able to showcase themselves to the national and global job market through the portal,” the Vice-Chancellor of MAKAUT, Professor Saikat Mitra, said. “The resume of the students will be extensively visible to potential employers. The portal will be a database of all students from MAKAUT colleges along with their academic and experience backgrounds,” Mitra said. The portal will also enable companies to post placement or internship opportunities, he said.last_img read more

Satisfy your sweet tooth with these sugarfree sweets

first_imgDespite the popularity of sugary treats, many health experts have noted how the increasing consumption of such products is leading to several serious diseases, such as diabetes. To curb the effect of sugar-based confectionaries, experts have suggested sugar-free treats that are a healthier alternative. Sugar free besan laddoos: While these come in several flavours, the most commonly available variant is besan laddoo, which is made with gram flour, ghee, and lots of sugar. Nevertheless, these days, many sweetmeat sellers and e-commerce platforms have begun to offer a healthier alternative that contains little to no sugar, and taste just as great.Khajoor roll: Khajoor, or dates, is the fruit from date palm trees, native to Middle-Eastern countries. It is also a popular dessert choice for the calorie-conscious. You can go for delectable khajoor rolls garnished with almond slivers for the perfectly healthy sweet treat.The sweet is prepared with honey instead of sugar and dates, combining two naturally sweet ingredients for a healthy after-meal snack.Anjeer (Fig) barfi: Anjeer, or fig is considered as one of the healthiest foods in the world due to the benefits it offers, such as improving digestion and controlling diabetes. This fruit can also be enjoyed in the form of anjeer barfi, an appetising treat that contains no refined sugar.These are usually made with cashew nuts, almonds, pistachios, figs, clarified butter (ghee), and honey, and are an excellent wholesome treat for both children and adults.Fini: Fini is a traditional Rajasthani sweet that originated in Bikaner. This delicacy looks like a bunch of hair due to its thin strands. It is made using flour, sugar, and pure ghee, making it an extremely sugary delight. On the other hand, its sugar-free variant is made using honey, so that you can curb your sugar intake without compromising on flavour.Lauki (bottle gourd) halwa: This sweet is a rather diabetic friendly treat which is made with just a teaspoon of ghee, bottle gourd, low fat milk, cardamom powder and stevia.Date coconut roll: This roll is made of only dates, almonds and a cup of desiccated coconut an packed with two grams of fibre. Date and apple kheer: You just need one chopped apple, low fat milk, dates and a teaspoon of crushed walnut for this sugar-free delight.last_img read more

Go back to the enewsletter Click the cover to view

first_imgGo back to the enewsletterClick the cover to view brochureScenic has debuted its new Egypt and Jordan 2019/2020 brochure with a new itinerary that takes guests to the ancient greatest wonders on Earth: the 14-day Egypt in-depth tour and cruise.From the majesty of the Great Pyramids of Giza to sailing on the Nile aboard the luxurious Sanctuary Sun Boat III, and from a Scenic Special Stay in the ancient city of Luxor to a two-night stay on the Red Sea, this itinerary offers a truly unique way of discovering the otherworldly beauty of the lands of the pharaohs.Unique to Scenic is the inclusion of all three palace hotels: Marriott Mena House, Sofitel Winter Palace Luxor and Sofitel Legend Old Cataract Aswan. These are properties of outstanding quality and character with pinch-yourself-views of the pyramids from the hotel veranda at the Mena House Hotel in Giza and sweeping views of the Nile from the Old Cataract Aswan.Scenic also includes a visit to Abu Simbel, which dates back to the 13th century BC and is one of Egypt’s most magnificent museums, as part of its regular itinerary. Abu Simbel is made up of two massive rock temples originally carved out of the mountainside. They serve as a lasting monument to the king and his queen Nefertari. The complex was relocated in its entirety in 1968, following the creation of Lake Nasser, when the entire site was carefully cut into large blocks and dismantled, lifted and reassembled in one of the greatest challenges of archaeological engineering in history.Image credit: Brian de BruyneThe Nile cruise on Sanctuary Sun Boat III caters for just 34 guests. This recently refurbished Nile cruiser evokes the heyday of Egypt’s past with its exquisite spaces, fine dining options and Sun Deck with swimming pool.New to the market is Scenic’s inclusion of a stay on the Red Sea in luxury at Kempinski Hotel Soma Bay on the shores of the Red Sea. Guests can relax and enjoy a day of leisure poolside or beachside, and enjoy Scenic Sundowners as the sun sets and spills an ocean of colour across the dramatic desert and seascapes.Image credit: Brian de BruyneScenic early-bird deals are available for bookings made by 15 December 2018. Options include:Free economy flights on any journey of 20 days or longer – a saving of up to $4,560 per couplePartner Fly Free on any journey less than 14 days – saving of up to $2,145 per coupleFly Business Class from only $5,495 per person on journeys of 20 days or longerSolo travellers save up to $1,000 off the single supplement on selected categories of the Nile CruiseBook by 15 December 2018 to receive the best offers for departures in 2019.Go back to the enewsletterlast_img read more

Video transport technology providers Nevion and T

first_imgVideo transport technology providers Nevion and T-VIPS have completed their merger. The combined company will trade under the Nevion name, with Geir Bryn-Jensen as CEO.Former T-VIPS CEO Johnny Dolvik joins as chief strategy officer, while chief operating officer and chief financial officer Janne Morstøl becomes chief product and marketing officer, and chief commercial officer Arnhild Schia continues her role in the new Nevion organization. Existing Nevion management team members Eugene Keane, chief technology officer, Nils Fredriksen, chief financial officer, and Petter Kvaal Djupvik, chief operating officer, will continue in their positions on the new team.last_img

The son of serially successful and controversial

first_imgThe son of serially successful (and controversial) mining magnate Robert Friedland, Govind was born and bred into the business. Smart, aggressive, charismatic, and driven, he has a degree in geology and geological engineering from the prestigious Colorado School of Mines, and has worked for his father’s company, Ivanhoe Mines, and for Kiewit Pacific. In 2006, he formed Govi High-Power Exploration, with interests in uranium and gold. Within a year, Govind had raised approximately C$100 million, to finance explorations and acquisitions, and to fund other GoviEx corporate initiatives. Displaying the same astute business sense that characterizes his father, Govind makes sure he’s a step ahead of the crowd. Thus a few years back, when Niger appeared on miners’ radar as the next frontier for uranium, GoviEx was already there. The company had staked out vast swaths of exploration land in the Arlit Basin, where French conglomerate Areva was producing. First Govind struck a deal to take over Semafo’s uranium assets in the West African country; in exchange, Semafo took a 12% stake in GoviEx. This brought the bigger companies knocking, and six months later Cameco (T.CCO), the world’s second-largest uranium producer, shelled out US$28 million for an 11% stake in GoviEx. Govind is working towards a public listing for GoviEx. According to a preliminary economic assessment prepared late 2010, the company’s Madaouela project could produce 2.7 million lbs. of U3O8 annually given a capital investment of $218 million. And Govind aims to more than double the resources at Madaouela, which currently stand at nearly 70 million indicated and inferred pounds. He may have inherited some mining genes, not to mention the best rolodex in the industry, but Govind Friedland is his own man, with the education, experience, and savvy to prove that he isn’t just riding his father’s coattails.last_img read more

Patients whose blood cancers have failed to respon

first_imgPatients whose blood cancers have failed to respond to repeated rounds of chemotherapy may be candidates for a new type of gene therapy that could send their cancers into remission for years. But the two approved therapies, with price tags of hundreds of thousands of dollars, have roiled the insurance approval process, leading to delays and, in some cases, denials of coverage, clinicians and analysts say.The therapy involves collecting patients’ own T cells, a type of white blood cell, genetically modifying them, and then infusing them back into patients, where they hunt down and kill cancer cells. Known as CAR-T cell therapy, it’s been characterized as a “living drug” by some researchers.Two different CAR-T drugs — Kymriah and Yescarta — were approved by the FDA last year to treat patients whose blood cancers haven’t responded to at least two other rounds of treatment.Kymriah is approved for people up to age 25 with a form of acute lymphoblastic leukemia, the most common cancer in children. Kymriah and Yescarta are both approved for adults with advanced lymphomas.Researchers report that some critically ill patients who received the therapy have remained cancer-free for as long as five years.”This is what patients need,” says Dr. Yi Lin, a hematologist who oversees the CAR-T cell practice and research for the Mayo Clinic. “With the likelihood of getting patients into durable survival, we don’t want to deny them the therapy.” She says she receives no personal financial support from the drugs’ makers.But the treatment comes at a cost — the drug treatments are hugely expensive. Kymriah and Yescarta cost $373,000 for a one-time infusion to treat adults with advanced lymphomas, while Kymriah costs $475,000 to treat acute lymphoblastic leukemia in children and young adults. That’s the cost of the drug itself; in addition, many patients experience serious side effects that can land them in a hospital intensive care unit for weeks, pushing treatment costs to more than $1 million.All of this gives government and private insurers pause.Most commercial insurers are covering CAR-T cell therapies now, but they do so on an individual basis, writing single-patient agreements each time, say cancer specialists. Large insurers that are already familiar with complicated therapies like stem-cell transplants are getting speedier at handling requests for CAR-T cell treatment, they say. But that’s not always the case at smaller or regional plans, where delays can add weeks to the approval process.”A request for CAR-T may end up with somebody on the payer authorization team who doesn’t understand the technology or the urgency of the request, when somebody has only weeks or months to live,” says Stephanie Farnia, director of health policy and strategic relations at the American Society for Blood and Marrow Transplantation.Farnia is in contact with many of the more than 50 medical centers that are authorized to provide treatment. The process of getting to a treatment center and evaluated for therapy is involved, she says. “To then be substantially delayed due to paperwork is incredibly frustrating” for patients.Medicare and Medicaid often pose greater coverage challenges than do private insurers, according to insurance experts.Some Medicaid programs don’t cover the treatment, says Dr. Michael Bishop, director of the cellular therapy program in the hematology/oncology section at the University of Chicago. Medicaid, the state-federal health program, covers children in low-income households and some adults.”Medicaid has been very tough,” he says. “Certain states just deny coverage — even states with balanced budgets.”States have to evaluate the cost as well as the drugs’ effectiveness, says Matt Salo, executive director of the National Association of Medicaid Directors.”Medicaid is a finite pot of money, and it’s stretched threadbare even on a good day,” he says.People who are on Medicare, the health insurance program for people age 65 and older and some people with disabilities, typically haven’t faced coverage denials to date, clinicians say. But the government’s reimbursement rates are raising concerns for providers.Last spring, Medicare announced payment rates for providers who administer Yescarta and Kymriah on an outpatient basis. The payments would more than cover the costs of the drugs. Medicare beneficiaries’ out-of-pocket costs would be capped at $1,340 plus the beneficiaries’ Part B deductible (if that hasn’t already been met), the agency says.The problem with this plan? Facilities typically provide treatment on an inpatient basis, not outpatient, because of the potential for severe, systemic side effects.”There’s a lot of toxicity and questions about whether it can even be provided in an outpatient setting,” says Gary Goldstein, the business manager at the blood and marrow transplant program at Stanford Health Care in Stanford, Calif.For inpatient care, “CAR-T cell therapy … would be paid at a much lower amount compared to outpatient hospital use,” according to officials at the Centers for Medicare & Medicaid Services.The agency is considering how to handle payment for inpatient CAR-T care for the fiscal year that starts in October. For now, some medical centers are absorbing whatever Medicare doesn’t pay.”How can you tell a patient who’s 66, ‘If only you’d gotten lymphoma when you were 64’?” Goldstein asks.But the current approach can’t continue indefinitely, he says.”Even if there aren’t any centers that are making that decision today, if coverage doesn’t change for Medicare, it absolutely is going to be a problem tomorrow,” says Goldstein.Kaiser Health News, a nonprofit news service, is an editorially independent program of the Kaiser Family Foundation, and is not affiliated with Kaiser Permanente. Michelle Andrews is on Twitter @mandrews110. Copyright 2018 Kaiser Health News. To see more, visit Kaiser Health News.last_img read more

Attention Cord Cutters YouTube TV Now Live

first_img April 6, 2017 Next Article Enroll Now for $5 The $35 monthly service offers live TV streaming from 50 networks for $35 per month. Reporter Add to Queue Attention, Cord Cutters: YouTube TV Now Live 2 min read Image credit: via PC Magcenter_img YouTube just made it a whole lot easier to cut the cord.The streaming giant on Wednesday officially launched YouTube TV, which it first tipped in February. The service offers live TV streaming from 50 networks, including ABC, CBS, FOX, NBC, ESPN, Fox Sports Networks, Comcast SportsNet, FX, USA, Disney Channel, Bravo, MSNBC and Fox News. The service will set you back $35 a month, which YouTube said is less than half the average cost of cable, but on par with rival services like Sling TV, which starts at $20 a month.For a full list of networks, check out the image below, though YouTube plans to add more networks to the roster in the near future, including AMC, BBC America, IFC, Sundance TV, WE tv and BBC World News. You can also add Showtime or Fox Soccer Plus for an extra charge.”YouTube TV gives you the best of live TV, from must-see shows like Empire, The Voice, The Big Bang Theory and Scandal, to the live sports you want from the NBA, MLB, NFL and NCAA,” YouTube wrote in its announcement. “Based on where you live, you’ll get your local broadcast TV stations covering local sports and news.”Subscribers also get access to a cloud DVR with no storage limits, though it only saves recordings for nine months. Subscribers can share their account with up to five friends or family members, and each person gets their own recommendations and access to the cloud DVR. As a household, you can watch up to three streams at a time.At this point, YouTube TV is only available in several large metro areas, including New York, Los Angeles, the San Francisco Bay Area, Chicago and Philadelphia. Try it out now free for a month; if you sign up, Google will give you a free Chromecast after your first month’s payment. You can also watch on your phone, tablet or computer. This story originally appeared on PCMag Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Angela Moscaritolo –shares YouTube Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful.last_img read more

World Health Organization Recommends Rescheduling Cannabis and Provides Clarity on CBD

first_img Image credit: razerbird | Getty Images Member states of the United Nations Commission on Narcotic Drugs (CND) received the World Health Organization Expert Committee on Drug Dependence’s (ECDD) cannabis recommendations, which had been expected in December, Marijuana Business Daily has learned.The CND had been expected to consider rescheduling cannabis in March 2019 at its annual meeting, but the delay in receiving the ECDD recommendations may push that consideration into 2020 to provide additional time for member states to review them.The report recommends several changes to how cannabis is scheduled, which could have significant implications for the cannabis industry:The scheduling of cannabis in the international drug control conventions wouldn’t be as restrictive as it is now, because it would be removed from Schedule IV of the 1961 Convention, the category reserved for the most dangerous substances.THC in all forms would be removed from the 1971 Convention and placed with cannabis in Schedule I of the 1961 Convention, significantly simplifying cannabis classification.Pure CBD and CBD preparations containing no more than 0.2 percent THC would not be included in any way in the international drug control conventions.Pharmaceutical preparations containing 9-THC, if they follow certain criteria, would be added to Schedule III of the 1961 Convention, recognizing the unlikelihood of abuse.MJBizDaily obtained and reviewed a copy of the recommendations — which have not yet been made public — on how to schedule different categories of cannabis and cannabis-related substances. Those changes include:Cannabis and cannabis resinThe report recommends cannabis and cannabis resin “be deleted from Schedule IV of the Single Convention on Narcotics Drugs (1961).” Schedule IV of the 1961 Convention, the most restrictive category, includes dangerous substances with extremely limited or no medical value.If this recommendation is followed, cannabis and cannabis resin instead would remain in Schedule I.In justifying the change, the ECDD noted:“The evidence presented to the Committee did not indicate that cannabis plant and cannabis resin were particularly liable to produce ill-effects similar to the effects of the other substances in Schedule IV of the 1961 Single Convention on Narcotic Drugs. In addition, preparations of cannabis have shown therapeutic potential for treatment of pain and other medical conditions such as epilepsy and spasticity associated with multiple sclerosis. In line with the above, cannabis and cannabis resin should be scheduled at a level of control that will prevent harm caused by cannabis use and at the same time will not act as a barrier to access and to research and development of cannabis-related preparation for medical use.”• Dronabinol (delta-9) and tetrahydrocannabinol (isomers of delta-9-THC)The report recommends that dronabinol and tetrahydrocannabinol (THC and its isomers) be “deleted from the Convention on Psychotropic Substances (1971) and added to Schedule I of the Single Convention on Narcotics Drugs (1961).” These recommendations would simplify the scheduling, grouping all forms of THC in the same category as cannabis and cannabis resin.The dangers associated with THC are similar to those of cannabis and cannabis resin, so it would be consistent to have them all together in the same category, the report noted.The report compares the reclassification to cocaine being in the same category as the coca leaf and morphine in the same category as opium. In the case of isomers of delta-9-tetrahydrocannabinol, the move would also simplify and bring consistency.“Due to the chemical similarity of each of the six isomers to delta-9-THC, it is very difficult to differentiate any of these six isomers from delta-9-THC using standard methods of chemical analysis,” the report said.Extracts and tinctures of cannabisThe report recommends that extracts and tinctures of cannabis be “deleted from Schedule I of the Single Convention on Narcotics Drugs (1961).”The committee recommended to delete this category from the 1961 Convention because extracts and tinctures encompass “diverse preparations with a variable concentration of delta-9 THC,” some being nonpsychoactive and with “promising therapeutic applications.”Cannabidiol preparationsThe ECDD previously finalized the critical review of pure CBD, recommending it not to be scheduled within the drug control conventions. Doubts remained about CBD preparations containing some THC, which the report clarified its position on:“The Committee recommended that a footnote be added to Schedule I of the 1961 Single Convention on Narcotic Drugs to read: ‘Preparations containing predominantly cannabidiol and not more than 0.2% of delta-9-tetrahydrocannabinol are not under international control.’”The committee also noted:“Cannabidiol is found in cannabis and cannabis resin but does not have psychoactive properties and has no potential for abuse and no potential to produce dependence. It does not have significant ill-effects. Cannabidiol has been shown to be effective in the management of certain treatment-resistant, childhood-onset epilepsy disorders. It was approved for this use in the United States in 2018 and is currently under consideration for approval by the EU.”Pharmaceutical preparations of cannabis and dronabinol.The Committee notes that there are currently two main types of medications containing delta-9-THC:Preparations that contains both delta-9-THC and CBD, such as Sativex.Preparations that contain only delta-9-THC as the active compound, such as Marinol or Syndros.Because “the evidence concerning the use of these delta-9-THC containing medicines is that they are not associated with problems of abuse and dependence and they are not diverted for the purpose of non-medical use,” and “in order not to impede access to these medicines,” the committee recommended not to include these medicines in the restrictive categories Schedule I of the 1961 or Schedule II of the 1971 Convention.Instead, the less restrictive Schedule III of the 1961 Convention was recommended:“The Committee recommended that preparations containing delta-9-tetrahydrocannabinol (dronabinol), produced either by chemical synthesis or as a preparation of cannabis, that are compounded as pharmaceutical preparations with one or more other ingredients and in such a way that delta-9-tetrahydrocannabinol (dronabinol) cannot be recovered by readily available means or in a yield which would constitute a risk to public health, be added to Schedule III of the 1961 Convention on Narcotic Drugs.”This article originally appeared in Marijuana Business Daily and is posted here under a content partnership with Green Entrepreneur. Listen Now Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. The WHO is on the verge of removing marijuana from the world’s list of dangerous narcotics while recognizing its vast therapeutic potential. Add to Queue Legal Marijuana Green Entrepreneur Podcastcenter_img 6 min read Brought to you by Marijuana Business Daily –shares February 6, 2019 Next Article World Health Organization Recommends Rescheduling Cannabis and Provides Clarity on CBDlast_img read more